Antibody-conjugated nanoparticles for target-specific drug delivery of chemotherapeutics

• Mamta Kumari,
• Amitabha Acharya and
• Praveen Thaggikuppe Krishnamurthy

Beilstein J. Nanotechnol. 2023, 14, 912–926, doi:10.3762/bjnano.14.75

• the theranostic applications of ACNPs for the treatment of cancer. Keywords: active targeting; chemical conjugation; chemotherapeutics; drug delivery; monoclonal antibody; Introduction Off-target side effects, such as myelosuppression, mucositis, alopecia, organ dysfunction, and thrombocytopenia

Cytotoxicity of doxorubicin-conjugated poly[N-(2-hydroxypropyl)methacrylamide]-modified γ-Fe₂O₃ nanoparticles towards human tumor cells

• Zdeněk Plichta,
• Yulia Kozak,
• Rostyslav Panchuk,
• Viktoria Sokolova,
• Matthias Epple,
• Lesya Kobylinska,
• Pavla Jendelová and
• Daniel Horák

Beilstein J. Nanotechnol. 2018, 9, 2533–2545, doi:10.3762/bjnano.9.236

• subsequent chemical conjugation with a specific drug. Dox-conjugated PHPMA was attached via hydrogen bonding between hydroxy groups on the superparamagnetic γ-Fe2O3 nanoparticle surface (citrate stabilization) and the C=O groups of the polymer. Due to the highly hydrophilic and flexible nature of PHPMA

Peptide-equipped tobacco mosaic virus templates for selective and controllable biomineral deposition

• Klara Altintoprak,
• Axel Seidenstücker,
• Alexander Welle,
• Sabine Eiben,
• Petia Atanasova,
• Nina Stitz,
• Alfred Plettl,
• Joachim Bill,
• Hartmut Gliemann,
• Holger Jeske,
• Dirk Rothenstein,
• Fania Geiger and
• Christina Wege

Beilstein J. Nanotechnol. 2015, 6, 1399–1412, doi:10.3762/bjnano.6.145

• of the template by chemical conjugation of peptides [16], poly(ethylene glycol) (PEG) [22], aniline [25][26], or succinamate [27] has been reported. Virus-based templates have gained especially important roles in the synthesis of organic–inorganic hybrid nanostructures. They combine several

• of mineralization-promoting peptides To nucleate and govern the deposition of silica shells, functionalized plant viral nanorod templates were generated by linker-assisted chemical conjugation of mineralization-active peptides to the outer surface of genetically modified TMVLys particles from plants

• virus particles with thousands of surface-exposed amino groups of lysine residues (TMVLys) served as biotemplates for chemical conjugation reactions. (b) Hetero-bifunctional linker molecules (succinimidyl-(N-maleimidopropionamido) ester, SM(PEG)4) were coupled to TMVLys via N-hydroxysuccinimide (NHS

Magnetic-Fe/Fe₃O₄-nanoparticle-bound SN38 as carboxylesterase-cleavable prodrug for the delivery to tumors within monocytes/macrophages

• Hongwang Wang,
• Tej B. Shrestha,
• Matthew T. Basel,
• Raj K. Dani,
• Gwi-Moon Seo,
• Sivasai Balivada,
• Marla M. Pyle,
• Heidy Prock,
• Olga B. Koper,
• Prem S. Thapa,
• David Moore,
• Ping Li,
• Viktor Chikan,
• Deryl L. Troyer and
• Stefan H. Bossmann

Beilstein J. Nanotechnol. 2012, 3, 444–455, doi:10.3762/bjnano.3.51

• vehicles that can incorporate SN38 by chemical conjugation or physical entrapment. Polymeric micelles, liposomes and thermally sensitive polymer-based nanoparticles, as well as multi-armed-PEG-functionalized nanographene oxide, have been used as carriers for the delivery of SN38 into biological systems [21